CP8-10 Actions of bisphosphonates on cancer in bone and non-bone sites
نویسندگان
چکیده
منابع مشابه
Bisphosphonates, bone, and breast cancer recurrence
Bisphosphonates reduce bone turnover by inhibiting osteoclast maturation and function, and are important in the prevention of age-related osteoporosis and bone fracture, in the prevention of complications of bone metastases, and in the prevention of osteopenia and osteoporosis resulting from adjuvant aromatase inhibitor therapy of breast cancer. Over 125 years ago, in The Lancet, Paget hypothes...
متن کاملBisphosphonates and Bone
Bisphosphonates are pyrophosphate analogues which were used for over a century in industry (mainly in the textile and oil industries) as antiscaling and anticorrosive agents because of their property of inhibition of calcium carbonate precipitation. After the discovery of biological effects of bisphosphonates more than 30 years ago, they have now become indispensable in medicine for the treatme...
متن کاملBisphosphonates: focus on inflammation and bone loss.
Bisphosphonates are pharmacological compounds that have been used for the prevention and treatment of several pathological conditions including osteoporosis, primary hyperparathyroidism, osteogenesis imperfecta, and other conditions characterized by bone fragility. Many studies have been performed to date to analyze their effects on inflammation and bone remodelling and related pathologies. The...
متن کاملBisphosphonates and metastatic bone disease.
Malignant bone disease is a frequent complication of several common solid tumours including breast, lung, prostate and renal cancer. A greater understanding of tropic bone tumour cells, especially the understanding of those properties which lead to their successful growth within the bone microenvironment is the first step to devise innovative approaches. Bone metastases are generally characteri...
متن کاملTreatment of bone metastases and bone pain with bisphosphonates.
Many solid tumors metastasize to bone, leading to debilitating skeletal complications such as intractable bone pain and pathologic fractures. Patients who experience a skeletal-related event (SRE) are at higher risk for subsequent events. After an SRE such as a pathologic fracture, spinal cord compression, or the requirement for orthopedic surgery or palliative radiation therapy, a patient's qu...
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ژورنال
عنوان ژورنال: The Japanese Journal of Urology
سال: 2004
ISSN: 0021-5287,1884-7110
DOI: 10.5980/jpnjurol.95.164